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r8 - 11 Jul 2008 - 16:32:17 - RaquellHOlmesYou are here: TWiki >  CompCellBio Web  >  TeachingModules > CellCycle

Teaching Module Description

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Module Name: Cell Cycle in Frog Egg Extracts
Author(s): Jill Sible and John Tyson
Module Biology Topic: Cell Cycle
Keywords: cyclin, Cdk, Cdc25, Wee1, hysteresis, bistability
UG Course Level: Beginner
Tool(s): XPP
Other tool: Edit to Insert Name and URL for Tool
Module Created: 2007/9/22

-- RaquellHOlmes - 02 Oct 2007

  • MPF.ode: ODE file for WinnPP? of the described model

Module

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Abstract DNA synthesis and mitosis in frog eggs is controlled by periodic synthesis and degradation of the cyclin subunit of a cyclin-dependent protein kinase, and also by periodic phosphorylation and dephosphorylation of the kinase subunit. We construct a differential-equation model of these reactions and show that, under reasonable conditions, the model can exhibit bistability (arrest in interphase or in mitosis) or spontaneous oscillations (periodic replication and division).
Physiology See Cell_Cycle_Module_Rev_1.doc
Model description See Cell_Cycle_Module_Rev_1.doc
Model files MPF.ode in WinnPP?
Model exercises See Cell_Cycle_Module_Rev_1.doc

___ CategoryModule

  • Cell Cycle Schematic:
    Cell_Cycle_Module_Rev_1.jpg
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Topic attachments
I Attachment Action Size Date Who Comment
pptppt figs_for_TWiki.ppt manage 214.5 K 24 Oct 2007 - 10:35 RaquellHOlmes Powerpoint figures of molecular biology and mathematical model
elseode MPF.ode manage 1.6 K 24 Oct 2007 - 14:17 RaquellHOlmes ODE file for WinnPP? of the described model
docdoc Cell_Cycle_Module_Answers.doc manage 50.0 K 26 Nov 2007 - 13:29 RaquellHOlmes Created by Sible and Tyson, this document provides answers to the exercises provided
docdoc Cell_Cycle_Module_Rev_1.doc manage 959.5 K 26 Nov 2007 - 13:37 RaquellHOlmes Full module description: revision 1. First version was deleted
jpgjpg Cell_Cycle_Module_Rev_1.jpg manage 69.0 K 11 Jul 2008 - 16:30 RaquellHOlmes Cell Cycle Figure 1
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