2008 All-Hands Meeting

March 20-21, 2008

Bethesda Marriott, Bethesda MD

Agenda

Thursday, March 20

8:00-8:30 a.m: Registration and Light Refreshments

8:30-8:45 a.m: Welcome, logistics, program update --- Doug Sheeley, NCRR

8:45 a.m: Overview of the NCDIR: from Proteomic Data to Macromolecular Structures --- JohnAitchison, Institute for Systems Biology

9:10 a.m: Late Processing and Nuclear Export of Large Ribonucleoprotein Complexes --- MarleneOeffinger, Rockefeller University

9:35 a.m: IMP:Software for Integrative Determination of Macromolecular Assembly Structures --- DanielRussel, UCSF

10:00 a.m: Revealing the HIV-Host Interactome --- Mark Muesing, Aaron Diamond AIDS Research Center

10:25-10:55 a.m:_Break_, Poster Viewing

10:55 a.m: Identification of Novel Proteolytic Pathways with Proteomics --- GuySalvesen, The Burnham Institute for Medical Research

11:20 a.m: Applying the CPP methodologies to anti-viral and anti-bacterial drug design --- AlexStrongin, The Burnham Institute for Medical Research

11:45 a.m: Proteolytic Pathways in Progression of Pre-Malignant Breast Disease --- BonnieSloane, Wayne State University

12:10 p.m: Predicting unknown Proteolytic Pathways: Charting new Research Directions --- Jeffrey W. Smith, The Burnham Institute for Medical Research

12:35- 2:00 p.m: Working Lunch for Registered Participants: Discussion of the TCNP Program: --- How can we improve the program going forward?

2:00 p.m: Massive mutagenesis of histones H3 and H4 --- Jef Boeke, Johns Hopkins

2:25 p.m: Global analysis of protein functions using a protein chip approach --- Heng Zhu, Johns Hopkins

2:50 p.m: Multi-scale systems analysis of chromatin structure --- Joel Bader, Johns Hopkins

3:15 p.m: Structural and biochemical analysis of the histone demethylase LSD1 --- Hongtao Yu, University of Texas Southwestern Medical Center

3:40-4:10 p.m: Break, Poster Viewing

4:10 p.m: Application of TCNP technologies to understand polarity in cell-cell fusion --- William Mohler, UCHC

4:35 p.m: Bringing new TCNP technologies to the education and research communities --- Raquell Holmes, UCHC

5:00-7:00 p.m: Adjourn for Dinner (on your own)

7:00-9:30 p.m: Poster Session

Friday, March 21

8:00-8:30 a.m: Registration and Light Refreshments

8:30 a.m. Biosensor platform development at the Fluorescent Probes and Imaging TCNP. --- AlanWaggoner, Carnegie Mellon University

8:55 a.m. Development of protease biosensors. --- PeterBerget and Crystal Falco, Carnegie Mellon University

9:20 a.m. Biosensors for endocytosis and exocytosis based on novel Fluorogen Activating Peptides and Fluorogens --- MarcelBruchez, Greg Fisher, Anmol Grover, John Holleran, Sally Adler, James Fitzpatrick, Jon Jarvik, Paul Johnston and John Lazo, Carnegie Mellon University and University of Pittsburgh

9:45 a.m. Analysis of microtubule ends in living regulatory mutants --- EstelleGlory, Rebecca Webb, Robert F. Murphy and Brooke McCartney^? Carnegie Mellon University

10:10-10:30 am Break, Poster Viewing

10:30 a.m. Applications of scFv based biosensors in immunology --- Russell Salter and SimonWatkins, University of Pittsburgh

10:55 a.m. "New technologies for modeling stochastic processes and diffusion in crowded spaces" --- BorisSlepchenko,UCHC

11:20 a.m. A new method to measure translational output from individual RNA molecules in live neurons using single molecule imaging --- JohnCarson, UCHC

11:45 a.m. Signaling platforms: manipulating the local concentration of signaling proteins in living cells --- BruceMayer, UCHC

12:10-1:30 p.m. Working Lunch for Registered Participants --- Discussion of Inter-TCNP Collaboration

Integration of PSLID and SLIF with “Virtual Cell” --- Robert F. Murphy, Les Loew and Ion Moraru Carnegie Mellon University and University of Connecticut Virtual geometries for spatial modeling of networks and pathways Ion Moraru, UCHC

1:30 p.m. Regulation of spatial domains of signaling components by cell shape --- Susana Neves, Mount Sinai School of Medicine

1:55 p.m. Integrating Virginia Tech and UCHC Technologies for Cell Cycle Modeling --- CliffShaffer, Virginia Tech

2:20 p.m. TBD --- Ileana Cristea, Princeton University

2:45 p.m. Analysis of signaling pathways in cancers using quantitative mass spectrometry --- Akhilesh Pandey, Johns Hopkins and Harold Varmus and Ugay Guha, Sloan Kettering

3:10 p.m. Closing Remarks

3:15 p.m. Adjourn